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Water → (S)-5-Oxopyrrolidine-3-carboxylic acid {1-(4-fluorophenyl)-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-yl}amide

HRID 83569
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HRID 83569 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][O:20][CH2:21][C:22]([F:25])([F:24])[F:23])[CH:14]=3)=[CH:11][C:10]([NH2:26])=[N:9]2)=[CH:4][CH:3]=1.[O:27]=[C:28]1[NH:32][CH2:31][C@@H:30]([C:33](O)=[O:34])[CH2:29]1.CCN=C=NCCCN(C)C.Cl.O>CN(C)C(=O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][O:20][CH2:21][C:22]([F:24])([F:23])[F:25])[CH:14]=3)=[CH:11][C:10]([NH:26][C:33]([C@H:30]3[CH2:29][C:28](=[O:27])[NH:32][CH2:31]3)=[O:34])=[N:9]2)=[CH:4][CH:3]=1
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참가 물질

6

반응물 4

HCID 962WaterHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 25100087(S)-5-oxopyrrolidine-3-carboxylic acidHCID 712877501-(4-Fluorophenyl)-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine

생성물 1

HCID 71287780(S)-5-Oxopyrrolidine-3-carboxylic acid {1-(4-fluorophenyl)-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-yl}amide
수율 46.4%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

To a solution of 1-(4-fluorophenyl)-5-[3-(2,2,2-trifluoroethoxymethyl)phenyl]-1H-pyrazol-3-ylamine (43 mg) in N,N-dimethylacetamide (0.4 ml) were sequentially added (S)-5-oxopyrrolidine-3-carboxylic acid (17 mg) prepared according to the same procedures as Preparation 5 and WSC.HCl (34 mg) at room temperature, and the mixture was stirred for 0.5 hours. To this reaction mixture was added water, and then the precipitated solid was collected by filtration. This solid was purified by silica gel thin-layer chromatography (eluent: chloroform/methanol=9/1). To the resulting solid were added water and a small amount of methanol, and the mixture was stirred. A solid was collected from this suspension by filtration, and was dried under reduced pressure to give the titled compound (26 mg).

후처리

  1. customprepared
  2. filtrationthe precipitated solid was collected by filtration
  3. customThis solid was purified by silica gel thin-layer chromatography (eluent: chloroform/methanol=9/1)
  4. additionTo the resulting solid were added water
  5. stirringa small amount of methanol, and the mixture was stirred
  6. filtrationA solid was collected from this suspension by filtration
  7. customwas dried under reduced pressure

출처 및 근거

ORD 기록
ord-c078ec6a0b8a4965bfbf6a78152c6047
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846746B2

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