Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 83774

반응식

HRID 83774 반응식
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

생성물 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochloride수율 77.6%

반응 조건

온도
10 °C

실험 절차

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2 (250 g, 77.6%) as a wheat colored powder.

후처리

  1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-9069b2e2cf384531903fee23e517008c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846845B2

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