6-(4-Nitrophenoxy)-hexanoic acid methyl ester → 6-(4-Nitrophenoxy)hexanoic acid

HRID 83804

반응식

HRID 83804 반응식
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1>Cl>[N+:16]([C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:15][CH:14]=1)([O-:18])=[O:17]

참가 물질

3

반응물 1

HCID 146502956-(4-Nitrophenoxy)-hexanoic acid methyl ester

생성물 1

HCID 223889056-(4-Nitrophenoxy)hexanoic acid수율 80.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

6-(4-nitrophenoxy)-hexanoic acid methyl ester 21 (125 g, 468.16 mmol) was refluxed in conc. HCl (1250 ml) for 16 hours. The reaction mixture was cooled to room temp., filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 35 (95 g, 80.2%) as a white powder with an m.p. between 104-107° C.

후처리

  1. temperatureThe reaction mixture was cooled to room temp.
  2. filtrationfiltered
  3. customdried
  4. customrecrystallised from a mixture of ethyl acetate:hexane (1:6)

출처 및 근거

ORD 기록
ord-547067b6166f49a6a94281f48d72b490
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846845B2

연결된 노트

불러오는 중…