Pyridine → N-(4-Iodophenyl)acetamide

HRID 8388

반응식

HRID 8388 반응식
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10].N1C=CC=CC=1>C(OCC)(=O)C>[CH3:10][C:9]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([I:1])=[CH:3][CH:4]=1)=[O:11]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 108934-Iodoaniline

생성물 1

HCID 12147N-(4-Iodophenyl)acetamide수율 99%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

4-Iodoaniline (11.0 g, 50.4 mmol) was dissolved in 60 mL of ethyl acetate and the solution was added with 10 mL of acetic anhydride (10.8 g, 106 mmol) and 7.8 mL of pyridine (7.65 g, 99.4 mmol), and the mixture was stirred at room temperature for 2 hours with an equipment of a CaCl2 tube. A solvent was evaporated under reduced pressure to obtain 4-iodoacetanilide (yield: 13.0 g, percent yield: 99.0%).

후처리

  1. customA solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f23b6d9e5abd4f8d9c2f50a4359ddf11
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087766B2

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