Hydrochloric Acid → N-Methyl-N'-hydroxy-N"-[4-(4-imidazolyl)butyl]guanidine dihydrochloride

HRID 839000노트

반응식

[CH3:1][NH:2][C:3]([NH:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[N:11]=[CH:12][NH:13][CH:14]=1)=S.[ClH:15].CNC(=NCCCCC1N=CNC=1)SC.[NH2:31][OH:32]>>[ClH:15].[ClH:15].[CH3:1][NH:2][C:3]([NH:31][OH:32])=[N:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[N:11]=[CH:12][NH:13][CH:14]=1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 787Hydroxylamine

HCID 178484951N,S-dimethyl-N'-[4-(4-imidazolyl)butyl]isothiourea

HCID 178486108N-[4-(1H-imidazol-5-yl)butyl]-N'-methylcarbamimidothioic acid

생성물 1

HCID 178484950N-Methyl-N'-hydroxy-N"-[4-(4-imidazolyl)butyl]guanidine dihydrochloride

실험 절차

When N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea is reacted with methanolic hydrogen chloride by the procedure of Example 1(i) the product is N,S-dimethyl-N'-[4-(4-imidazolyl)butyl]isothiourea which on treatment with hydroxylamine by the procedure of Example 1(ii) gives the title product.

출처 및 근거

ORD 기록: ord-3e664da6134e4171ae1d49a6eab6ba5e
출처 데이터셋: uspto-grants-1978_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04093729

반응 노트

불러오는 중…