Succinic anhydride → 4-Chloro-3-succinimido-5-sulphamylbenzoic acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([Cl:14])=[C:6]([NH2:15])[CH:5]=1.[C:17]1(=O)[O:22][C:20](=[O:21])[CH2:19][CH2:18]1>CO>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[C:7]([Cl:14])=[C:6]([N:15]2[C:20](=[O:21])[CH2:19][CH2:18][C:17]2=[O:22])[CH:5]=1참가 물질
4
실험 절차
25.4 g of 4-chloro-3-amino-5-sulphamyl-benzoic acid methyl ester, m.p. 195°-196° C, are thoroughly mixed with 25 g of succinic acid anhydride and melted for 6 hours at 180° C. The melt is allowed to cool slowly and CH3OH is added carefully. The product crystallizes. A small amount of water added completes the crystallisation.
후처리
- temperatureto cool slowly
- customThe product crystallizes
- customA small amount of water added completes the crystallisation
출처 및 근거
- ORD 기록
- ord-27c818fcd15343d2ae1d82e54eba3986
- 출처 데이터셋
- uspto-grants-1978_06
- 특허 번호
- US04093735
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