Hydrochloric Acid → 4-Hydroxymethyl-2-p-methoxyphenyl-5-methyl-imidazole hydrochloride

HRID 839126노트

반응식

HRID 839126 반응식
[ClH:1].C([O:5][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12])(C)C.Cl>O>[ClH:1].[OH:5][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 203258814-Isopropoxymethyl-2-(p-methoxyphenyl)-5-methylimidazole hydrochloride

생성물 1

HCID 203258964-Hydroxymethyl-2-p-methoxyphenyl-5-methyl-imidazole hydrochloride수율 94.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4-isopropoxymethyl-2-(p-methoxyphenyl)-5-methylimidazole hydrochloride (48.9 g, 0.164 mole) in 500 ml of water is stirred and refluxed. To this mixture is added 50 ml of concentrated hydrochloric acid and stirring and refluxing are continued for 4 hrs. The mixture is then chilled and filtered to give about 39.5 g (94%) of 4-hydroxymethyl-2-(p-methoxyphenyl)-5-methylimidazole hydrochloride which is recrystallized from isopropyl alcohol, m.p. 146°-148° C (dec.). Treatment with alkali (e.g., NaOH) affords the corresponding base form.

후처리

  1. temperaturerefluxed
  2. stirringstirring
  3. temperaturerefluxing
  4. temperatureThe mixture is then chilled
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-87b5c2953a6b4bae8a0da0c78ec64c46
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04093811

반응 노트

불러오는 중…