Ammonia → HCID 178526568, 화합물

HRID 839194노트

반응식

HRID 839194 반응식
N.[CH2:2]1[O:23][CH:5]([C:6]2[C:7]([C:15]3[O:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=3)=[N:8][N:9](C(OC)=O)[CH:10]=2)[O:4][CH2:3]1.Cl>O>[CH2:3]1[O:4][CH:5]([C:6]2[C:7]([C:15]3[O:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=3)=[N:8][NH:9][CH:10]=2)[O:23][CH2:2]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 203260461-Methoxycarbonyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehyde-ethyleneacetal

생성물 1

HCID 178526568HCID 178526568, 화합물수율 79%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Add 29 ml of concentrated ammonia solution (in 200 ml. of dimethylformamide and 50 ml of water) dropwise at room temperature to a suspension of 51 g of 1-methoxycarbonyl-3-(5-nitro-2-furyl)pyrazole-4-carboxaldehyde-ethyleneacetal. Stir for 20 minutes until dissolution takes place. Acidify with 2N hydrochloric acid to a pH of from 5 to 6 to throw down a precipitate. Add 50 ml of water dropwise, stir for a further 15 minutes at room temperture, draw off the precipitate and wash with water to obtain 3-(5-nitro-2-furyl)-1H-pyrazole-4-carboxaldehyde-ethyleneacetal [m.p. 166° to 167° C]with a yield of 79%.

후처리

  1. stirringstir for a further 15 minutes at room temperture
  2. washwash with water

출처 및 근거

ORD 기록
ord-ccc229eb4ee24bd59a7f85e7aec88193
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04093812

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