Hydrochloric Acid → 5-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid

HRID 839420노트

반응식

HRID 839420 반응식
[C:1]([O:8]C)(=[O:7])/[CH:2]=[CH:3]\[C:4]([O-])=[O:5].[NH:10]([C:12]1[CH:17]=[CH:16][C:15]([S:18]([O-:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1)[NH2:11].C(=O)([O-])[O-].[Na+].[Na+].Cl>O>[C:1]([CH:2]1[CH2:3][C:4](=[O:5])[N:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([OH:21])(=[O:19])=[O:20])=[CH:14][CH:13]=2)[NH:11]1)([OH:8])=[O:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 10340Sodium Carbonate2회HCID 1549500p-Hydrazinobenzene sulphonateHCID 21768182Mono-methyl maleate

생성물 1

HCID 203245745-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid수율 85%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

110 parts of monomethyl maleate are added with stirring to 800 parts of water containing 152 parts of p-hydrazinobenzene sulphonate and 88 parts of sodium carbonate. The mixture is warmed until all reactants are in solution and the pH is adjusted by addition of sodium carbonate to 7.0. The resulting solution is heated at 100° C for 9 hours during which period the pH is adjusted to 7.0 after 6 hours. On completion of heating, the pH is adjusted to 3.8 by addition of hydrochloric acid and the 3-carboxy-1-(4'-sulphophenyl)-5-pyrazolidone thus formed is filtered off and dried between 50°-100° C. The actual weight yield is 266 parts of strength 77% (determined by N.M.R.) which represents a yield of 85% theory.

후처리

  1. temperatureThe mixture is warmed until all reactants
  2. temperatureOn completion of heating

출처 및 근거

ORD 기록
ord-046cfddd66d842988d0e86b3e26fec6f
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04095024

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