Hydrochloric Acid → 5-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid

HRID 839423노트

반응식

HRID 839423 반응식
[C:1]([O:8]C)(=[O:7])/[CH:2]=[CH:3]\[C:4]([O-])=[O:5].[NH:10]([C:12]1[CH:17]=[CH:16][C:15]([S:18]([O-:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1)[NH2:11].C(=O)([O-])[O-].[Na+].[Na+].Cl>O>[C:1]([CH:2]1[CH2:3][C:4](=[O:5])[N:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([OH:21])(=[O:19])=[O:20])=[CH:14][CH:13]=2)[NH:11]1)([OH:8])=[O:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 10340Sodium Carbonate2회HCID 1549500p-Hydrazinobenzene sulphonateHCID 21768182Mono-methyl maleate

생성물 1

HCID 203245745-Oxo-1-(4-sulfophenyl)pyrazolidine-3-carboxylic acid수율 89%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

50 parts of monomethyl maleate are added with stirring to 400 parts of water containing 70 parts of p-hydrazinobenzene sulphonate and 39 parts of sodium carbonate. The mixture is warmed until all reactants are in solution and the pH is adjusted by sodium carbonate to 9.2. The resulting solution is heated at 100° C for 9 hours. On completion of heating, the pH is adjusted to 3.8 by addition of hydrochloric acid and the 3-carboxy-1-(4'-sulphophenyl)-5-pyrazolidone thus formed is recovered and dried between 50°-100° C. The actual weight yield is 140 parts of strength 70% (determined by N.M.R.) which represents a yield of 89% of the theory.

후처리

  1. temperatureThe mixture is warmed until all reactants
  2. temperatureOn completion of heating

출처 및 근거

ORD 기록
ord-45b863d13b1a4adda52f0d8bce9265c1
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04095024

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