Methyl iodide → 2-[Acetyl(2,2-diethoxyethyl)amino]-1-methylpyridin-1-ium iodide

HRID 839616노트

반응식

HRID 839616 반응식
[CH2:1]([O:3][CH:4]([O:16][CH2:17][CH3:18])[CH2:5][N:6]([C:13](=[O:15])[CH3:14])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:2].[CH3:19][I:20]>C(O)C>[I-:20].[CH3:19][N+:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[N:6]([C:13](=[O:15])[CH3:14])[CH2:5][CH:4]([O:16][CH2:17][CH3:18])[O:3][CH2:1][CH3:2]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 20323729HCID 20323729, 화합물

생성물 1

HCID 203237172-[Acetyl(2,2-diethoxyethyl)amino]-1-methylpyridin-1-ium iodide수율 96%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

A mixture of N-acetyl-N-(2-pyridyl)-aminoacetaldehyde diethyl acetal (6.0 g.), methyl iodide (25 g.) and ethanol (30 ml.) was heated for 15 hours at 60° C in a sealed tube. The reaction mixture was concentrated and water was added to the residual oil. The mixture was washed twice with ether and the aqueous layer was concentrated under reduced pressure to give oil of 1-methyl-2-[N-acetyl-N-(2,2-diethoxyethyl)-amino]-pyridinium iodide (9.0 g.).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added to the residual oil
  3. washThe mixture was washed twice with ether
  4. concentrationthe aqueous layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-2e73f7b8b5a2407cbc17f05f6a155811
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04096263

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