Acetic Anhydride → 1-[2-(Propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]ethan-1-one

HRID 839792노트

반응식

HRID 839792 반응식
[CH:1]([C:4]1[CH:12]=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1)([CH3:3])[CH3:2].[C:13](OC(=O)C)(=[O:15])[CH3:14]>S(=O)(=O)(O)O.[OH-].[K+]>[C:13]([C:12]1[C:4]([CH:1]([CH3:3])[CH3:2])=[N:5][N:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=12)(=[O:15])[CH3:14]

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 113786582-Isopropylpyrazolo[1,5-a]pyridine

생성물 1

HCID 159338551-[2-(Propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]ethan-1-one수율 81.1%

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 14797Potassium Hydroxide용매

실험 절차

A mixture of 4.2g of 2-isopropylpyrazolo[1,5-a]-pyridine, 10.2g of acetic anhydride and 2-3 drops of concentrated sulfuric acid was refluxed for 7 hr. After cooling, the mixture was added to 200 ml of 4M potassium hydroxide solution and stirred for 1 hr. The solution was extracted with chloroform and the chloroform solution was dried over sodium sulfate. The dried chloroform solution was concentrated and the residue was columnchromatographed over alumina to isolate objective product. Recrystallization from n-hexane gave 4.3g of colorless needles, mp 74° C. Yield 67%.

후처리

  1. temperaturewas refluxed for 7 hr
  2. temperatureAfter cooling
  3. extractionThe solution was extracted with chloroform
  4. dry with materialthe chloroform solution was dried over sodium sulfate
  5. concentrationThe dried chloroform solution was concentrated
  6. customto isolate objective product
  7. customRecrystallization from n-hexane

출처 및 근거

ORD 기록
ord-7501d1dc34534a46a42280ac97b4d82c
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04097483

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