Promethazine Hydrochloride → Thiazinamium Metilsulfate

HRID 839902

반응식

HRID 839902 반응식
[CH3:1][CH:2]([N:18]([CH3:20])[CH3:19])[CH2:3][N:4]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[S:11][C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]1=2.Cl.[S:22]([O:27]C)([O:25][CH3:26])(=[O:24])=[O:23]>CC(C)=O>[CH3:26][O:25][S:22]([O-:27])(=[O:24])=[O:23].[CH3:20][N+:18]([CH3:26])([CH3:19])[CH:2]([CH3:1])[CH2:3][N:4]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=2[S:11][C:12]2[C:13]1=[CH:14][CH:15]=[CH:16][CH:17]=2

참가 물질

4

반응물 2

HCID 6014Promethazine HydrochlorideHCID 6497Dimethyl Sulfate2회

생성물 1

HCID 6015Thiazinamium Metilsulfate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

dl-Promethazine hydrochloride (30 g.) was converted to the free base and was dissolved in absolute acetone and dimethyl sulfate (10 g.) was added (this is less than are equivalent of dimethyl sulfate due to its hazardous nature). After standing overnight, the solution was heated on a steam bath and cooled. The precipitated solid was filtered, washed with tetrahydrofuran and ether to provide dl-trimethyl[1-methyl-2-(phenothiazine-10-yl)ethyl]ammonium methyl sulfate, 27.6 g., m.p. 170°-173° C.

후처리

  1. temperaturethe solution was heated on a steam bath
  2. temperaturecooled
  3. filtrationThe precipitated solid was filtered
  4. washwashed with tetrahydrofuran and ether

출처 및 근거

ORD 기록
ord-bec2f61d3bcb4d9a9934737b21c253d8
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04097596

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