Methyl iodide → HCID 178488729, 화합물

HRID 839962

반응식

HRID 839962 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]3[CH:17]=2)=[CH:5][CH:4]=1.[CH3:18][I:19]>C(#N)C>[I-:19].[CH3:18][N+:10]1[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[CH:17][N:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=12

참가 물질

4

반응물 2

HCID 6328Methyl iodide2회HCID 6949632-(4-Methoxyphenyl)imidazo[1,2-a]pyridine

생성물 1

HCID 178488729HCID 178488729, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To 2.23 g. of 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine in 50 ml. of acetonitrile is added 2.84 g. of methyl iodide, and the resulting reaction mixture refluxed for 3 hrs. Additional methyl iodide (2 ml.) is added and reflux continued for one hour. The solids which precipitate on cooling are filtered and partially dissolved in boiling isopropanol and filtered. The isopropanol filtrate is cooled and treated with diethyl ether. The crystallized product is filtered and dried to give 1.03 g., m.p. 194°-196° C.

후처리

  1. temperaturerefluxed for 3 hrs
  2. temperaturereflux
  3. customThe solids which precipitate
  4. temperatureon cooling
  5. filtrationare filtered
  6. dissolutionpartially dissolved
  7. filtrationfiltered
  8. temperatureThe isopropanol filtrate is cooled
  9. additiontreated with diethyl ether
  10. filtrationThe crystallized product is filtered
  11. customdried
  12. customto give 1.03 g

출처 및 근거

ORD 기록
ord-c00f559c72d040ff985b6198d0640a89
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04097598

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