Ethylene Oxide → HCID 20322512, 화합물

HRID 840005노트

반응식

HRID 840005 반응식
[CH2:1]([C:3]1([CH3:27])[NH:22][C:21]([CH2:24][CH3:25])([CH3:23])[CH2:20][C:5]2([NH:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6]2=[O:19])[CH:4]1[CH3:26])[CH3:2].[CH2:28]1[O:30][CH2:29]1>CO.Cl>[CH2:1]([C:3]1([CH3:27])[N:22]([CH2:28][CH2:29][OH:30])[C:21]([CH2:24][CH3:25])([CH3:23])[CH2:20][C:5]2([NH:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6]2=[O:19])[CH:4]1[CH3:26])[CH3:2]

참가 물질

5

반응물 2

HCID 6354Ethylene OxideHCID 20322535HCID 20322535, 화합물2회

생성물 1

HCID 20322512HCID 20322512, 화합물수율 97.1%

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 887Methanol용매

반응 조건

온도
110 °C

실험 절차

To a solution of 6.0 g of 7,9-diethyl-6,7,9-trimethyl-3-octyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (Compound 5) obtained as described in Example 4, in 40 ml of methanol were added 3 drops of concentrated hydrochloric acid and 3.5 g of ethylene oxide. The mixture was heated at 110° C for 24 hours in a sealed tube and then concentrated to give 6.5 g of Compound 118 as an oil. This product had an Rf value of 0.33 on thin layer chromatography on a 0.25 mm thick layer of silica gel (Kieselgel 60F 254, available from Merck & Co.; eluent, benzene containing 5% of triethylamine).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a3d84470103c40a1820caca10150dcb0
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04097587

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