Benzyl Bromide → 3-Phenyl-5-(3-phenylpropyl)isoxazole-4-carboxylic acid

HRID 840131

반응식

HRID 840131 반응식
[C:1]1([C:7]2[C:11]([C:12]([OH:14])=[O:13])=[C:10]([CH2:15][CH2:16]C3C=CC=CC=3)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:1]1([C:7]2[C:11]([C:12]([OH:14])=[O:13])=[C:10]([CH2:15][CH2:16][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 7498Benzyl BromideHCID 234479063-Phenyl-5-(2-phenylethyl)isoxazole-4-carboxylic acid

생성물 1

HCID 234478873-Phenyl-5-(3-phenylpropyl)isoxazole-4-carboxylic acid수율 72%

실험 절차

The title compound was prepared as described for Compound 28A but substituting 2-phenylethylbromide for benzyl bromide. The crude was purified by flash chromatography (ethyl acetate-petroleum ether-acetic acid 1:1:0.01 mL) to afford the title compound (72%).

후처리

  1. customThe title compound was prepared
  2. customThe crude was purified by flash chromatography (ethyl acetate-petroleum ether-acetic acid 1:1:0.01 mL)

출처 및 근거

ORD 기록
ord-5384ec8b06e24c5a8f96afdfd5615e71
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06365591B1

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