Acetanilide → 4'-Chloroacetyl(acetanilide)

HRID 840167노트

반응식

HRID 840167 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:8])[CH3:7].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCCl>[Cl:1][CH2:2][C:3]([C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:6](=[O:8])[CH3:7])=[CH:11][CH:12]=1)=[O:4]

참가 물질

5

반응물 3

HCID 904AcetanilideHCID 6577Chloroacetyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 88054'-Chloroacetyl(acetanilide)

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

반응 조건

온도
60 °C

실험 절차

23.5 mmol of chloroacetyl chloride and, in portions, 18.1 mmol of acetanilide, are added slowly, under an argon atmosphere, to 108 mmol of aluminium chloride in 90 ml of 1,2-dichloroethane. The reaction mixture is heated at 60° C. for 2 hours and then cooled with an ice bath. After slow hydrolysis using ice, and filtration, the precipitate obtained is washed with ethyl ether and dried. The expected product so obtained is used in the following without being purified.

후처리

  1. temperaturecooled with an ice bath
  2. customAfter slow hydrolysis
  3. filtrationice, and filtration
  4. customthe precipitate obtained
  5. washis washed with ethyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-8302ee1b619a44479dd5e646e1a4a518
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06365605B1

반응 노트

불러오는 중…