Sodium Hydroxide → Sodium 2-bromo-5-methylbenzene-1-sulfinate

HRID 840650노트

반응식

HRID 840650 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([OH:11])=[O:10].[OH-].[Na+:13]>CO.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([O-:11])=[O:10].[Na+:13]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 151553372-Bromo-5-methylbenzenesulfinic acid

생성물 1

HCID 23677276Sodium 2-bromo-5-methylbenzene-1-sulfinate

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

49.6 g of 2-bromo-5-methylbenzenesulfinic acid are dissolved in 400 ml of methanol and treated with an equimolar amount of NaOH in 50 ml of water. The mixture is stirred at RT for 3 hours, the solution is filtered off and the solvents are then removed in vacuo. Finally, residues of water are removed azeotropically using 50 ml of toluene. The solid residue is dried in vacuo over P4O10 and 54.0 g of product are obtained, mp 288-290° C. (with decomposition).

후처리

  1. filtrationthe solution is filtered off
  2. customthe solvents are then removed in vacuo
  3. customFinally, residues of water are removed azeotropically
  4. dry with materialThe solid residue is dried in vacuo over P4O10 and 54.0 g of product
  5. customare obtained

출처 및 근거

ORD 기록
ord-fc99cf30ebc84e6681e878695df449a7
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06369069B1

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