Sodium Hydroxide → Sodium 2-bromo-5-methylbenzene-1-sulfinate

HRID 841114노트

반응식

HRID 841114 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([OH:11])=[O:10].[OH-].[Na+:13]>CO.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[S:9]([O-:11])=[O:10].[Na+:13]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 151553372-Bromo-5-methylbenzenesulfinic acid

생성물 1

HCID 23677276Sodium 2-bromo-5-methylbenzene-1-sulfinate

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

49.6 g of 2-bromo-5-methylbenzenesulfinic acid are dissolved in 400 ml of methanol and treated with an equimolar amount of NaOH in 50 ml of water. The mixture is stirred at RT for 3 hours, the solution is filtered off and subsequently the solvents are removed in vacuo. Finally, water residues are removed azeotropically with 50 ml of toluene. The solid residue is dried over P4O10 in vacuo and 54.0 g of product are obtained, mp 288-290° C. (with decomposition).

후처리

  1. filtrationthe solution is filtered off
  2. customsubsequently the solvents are removed in vacuo
  3. customFinally, water residues are removed azeotropically with 50 ml of toluene
  4. dry with materialThe solid residue is dried over P4O10 in vacuo and 54.0 g of product
  5. customare obtained

출처 및 근거

ORD 기록
ord-a91ae303c4224422aa673b0a89744d80
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06369236B1

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