Hydrochloric Acid → p-(Octylthiomethyl)benzyl chloride

HRID 8423

반응식

HRID 8423 반응식
CC(C)([O-])C.[Na+].[CH2:7]([SH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[C:16]1([CH2:24]Cl)[CH:21]=[CH:20][C:19]([CH2:22][Cl:23])=[CH:18][CH:17]=1.Cl>CO>[CH2:7]([S:15][CH2:24][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][Cl:23])=[CH:18][CH:17]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 81441-OctanethiolHCID 12171alpha,alpha'-Dichloro-p-xyleneHCID 23676156Sodium t-butoxide

생성물 1

HCID 10613099p-(Octylthiomethyl)benzyl chloride

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

1.83 g (19 mmol) of sodium t-butoxide and 2.78 g (19 mmol) of octanethiol were stirred into 40 g of methanol at room temperature. After 30 minutes, the clear solution was added in one portion to 3.33 g (19 mmol) of p-xylylene dichloride in 100 g of methanol. After one hour, the mixture was neutralized using 1N hydrochloric acid, and all the volatile components were removed under reduced pressure. The crude product was taken up in 250 ml of chloroform and washed twice with 100 ml of water each time, dried and evaporated under reduced pressure. 5.29 g, which, according to 1H-NMR-spectroscopy, consisted of 50% of product, 25% of starting material and 25% of p-bis(octylthiomethyl)benzene.

후처리

  1. waitAfter one hour
  2. customall the volatile components were removed under reduced pressure
  3. washwashed twice with 100 ml of water each time
  4. customdried
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-1dafe2e64013446290804c2d6d9417a2
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087787B1

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