Sodium Hydroxide → 1,3-Dihydroisobenzofuran

반응식

[OH-].[Na+].O[CH2:4][C:5]1[C:6]([CH2:11][OH:12])=[CH:7][CH:8]=[CH:9][CH:10]=1>>[CH2:11]1[O:12][CH2:4][C:5]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2

참가 물질

반응물 2

HCID 14798Sodium Hydroxide

HCID 691531,2-Benzenedimethanol

생성물 1

HCID 103271,3-Dihydroisobenzofuran수율 96%

실험 절차

The procedure of Example 15 was performed except that the pH of the reaction mixture was regulated to 12 by use of sodium hydroxide. The reaction mixture was sampled for analysis. Formation of α,α′-dihydroxy-o-xylene was not observed. Instead, phthalan was formed at a yield of 96% based on α,α′-dichloro-o-xylene.

후처리

aliquotThe reaction mixture was sampled for analysis

출처 및 근거

ORD 기록: ord-691be264de8b49cb99250fc961fc3048
출처 데이터셋: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06372921B1

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