Water → 3-Chloro-2-cyanopyrazine 1-oxide

HRID 842617

반응식

HRID 842617 반응식
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[N:6][CH:5]=[CH:4][N:3]=1.[OH2:10]>OS(O)(=O)=O>[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[N+:6]([O-:10])[CH:5]=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 2924653-Chloropyrazine-2-carbonitrile

생성물 1

HCID 107969923-Chloro-2-cyanopyrazine 1-oxide

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

2-Chloro-3-cyanopyrazine (5.00 g, 35.94 mmol) in concentrated H2SO4 (35 mL) at 0° C. was treated portionwise with K2S2O8 (11.65 g, 43.95 mmol), warmed to room temperature, stirred for 24 hours, treated with water, and extracted with chloroform. The organic extract was washed sequentially with water, saturated NaHCO3 and brine, dried (MgSO4) and concentrated to provide the title compound. MS (DCI/NH3) m/e 173 (M+NH4)+.

후처리

  1. extractionextracted with chloroform
  2. extractionThe organic extract
  3. washwas washed sequentially with water, saturated NaHCO3 and brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-aff5277d64c849fdb0f118686d72d8e9
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376488B1

연결된 노트

불러오는 중…