Hydrochloric Acid → HCID 2907754, 화합물

HRID 842770노트

반응식

HRID 842770 반응식
C1O[C:4]2([CH2:9][CH2:8][N:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N+:16]([O-:18])=[O:17])[CH2:6][CH2:5]2)[O:3]C1.Cl>CCOCC>[N+:16]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:7]1[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]1)([O-:18])=[O:17]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22220290HCID 22220290, 화합물

생성물 1

HCID 2907754HCID 2907754, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 7 (7.44 g, 28.1 mmol) in ether (300 mL) was treated with 5% aqueous HCl (150 mL). The mixture was stirred at room temperature (5 d). The reaction was quenched with solid sodium bicarbonate. The aqueous layer was extracted with three additional portions of ether and the combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. Flash chromatography on silica gel (20% ethyl acetate/hexane) afforded the title compound (8).

후처리

  1. customThe reaction was quenched with solid sodium bicarbonate
  2. extractionThe aqueous layer was extracted with three additional portions of ether
  3. washthe combined organic extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-88dd68d431cd42739171bad06f610338
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376503B1

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