Hydrochloric Acid → HCID 18727059, 화합물

HRID 842772노트

반응식

HRID 842772 반응식
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N+:23]([O-:25])=[O:24])[CH2:13][CH2:12]1)(C)(C)C.Cl>C(OCC)(=O)C>[N+:23]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[N:14]1[CH2:13][CH2:12][CH:11]([NH:10][CH2:9][CH2:8][NH2:7])[CH2:16][CH2:15]1)([O-:25])=[O:24]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 18727100HCID 18727100, 화합물

생성물 1

HCID 18727059HCID 18727059, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 9 (576 mg, 1.66 mmol) in ethyl acetate (50 mL) was cooled to 0° C. and treated with anhydrous HCl (5 min). The mixture was. stirred at room temperature (2 h). The solvent was removed in vacuo and the residue disolved in dichloromethane and sodium carbonate solution. The aqueous layer was extracted with two additional portions of dichloromethane. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound (10). The crude product was used directly.

후처리

  1. customThe solvent was removed in vacuo
  2. extractionThe aqueous layer was extracted with two additional portions of dichloromethane
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-fc068f8f6a98425c87c7912bb1ea067d
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376503B1

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