Hydrochloric Acid → N-(2-Cyano-4-methylphenyl)-4-piperidone

HRID 842783노트

반응식

HRID 842783 반응식
C1O[C:5]2([CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:12]=3[C:18]#[N:19])[CH2:7][CH2:6]2)[O:4]C1C.Cl>CCOCC>[C:18]([C:12]1[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:11]=1[N:8]1[CH2:9][CH2:10][C:5](=[O:4])[CH2:6][CH2:7]1)#[N:19]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86757963N-(2-Cyano-4-methylphenyl)-4-piperidone propylene ketal

생성물 1

HCID 22615416N-(2-Cyano-4-methylphenyl)-4-piperidone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 29 (549 mg, 2.00 mmol) in ether (20 mL) was treated with 3N aqueous HCl (25 mL). The mixture was stirred at room temperature (24 h). The solvent was removed in vacuo and the residue dissolved in 6N HCl (25 mL) and acetic acid (10 mL). The mixture was stirred at room temperature (3 h). The reaction mixture was neutralized with sodium carbonate solution and the aqueous layer was extracted with three portions of ether. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound (30).

후처리

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue dissolved in 6N HCl (25 mL)
  3. stirringThe mixture was stirred at room temperature (3 h)
  4. extractionthe aqueous layer was extracted with three portions of ether
  5. washThe combined organic extracts were washed with brine
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-87f8721a71604261af6e2c1230d3796f
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376503B1

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