Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

HRID 8429

반응식

HRID 8429 반응식
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])[O-].[K+].[K+].CS(O[C@H:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24])(=O)=O>[Cl-].C([N+](CCCCCC)(CCCCCC)CCCCCC)CCCCC>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][C@@H:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 774682,3,4-TrifluoroanilineHCID 57320743Methyl (2R)-2-[(methylsulfonyl)oxy]propanoate

생성물 1

HCID 10125210Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

시약·촉매·용매 1

HCID 80021Tetrahexylammonium chloride촉매

실험 절차

In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-2-[(methanesulfonyl)oxy]propionate (78 mg) and tetrahexylammonium chloride (40 mg) to give the title compound as an oily substance. As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 38 mg (24%) of the title compound.

후처리

  1. customIn accordance with the process of Example 2, a condensation reaction

출처 및 근거

ORD 기록
ord-d9b0bffd894b426d850fcbbf6660c959
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087778B2

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