Isopropanol → Diisopropyl (S)-(-)-malate

HRID 843280노트

반응식

HRID 843280 반응식
[C:1]([OH:9])(=[O:8])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3].[C:10]1(C)[CH:15]=CC(S(O)(=O)=O)=C[CH:11]=1.[CH:21](O)([CH3:23])[CH3:22]>>[C:1]([O:9][CH:21]([CH3:23])[CH3:22])(=[O:8])[C@H:2]([CH2:4][C:5]([O:7][CH:10]([CH3:15])[CH3:11])=[O:6])[OH:3]

참가 물질

4

반응물 3

HCID 3776IsopropanolHCID 6101p-Toluenesulfonic acidHCID 222656L-Malic Acid

생성물 1

HCID 11333435Diisopropyl (S)-(-)-malate

실험 절차

(S)-malic acid was dissolved in isopropanol and p-toluenesulphonic acid (cat) was added and stirred at room temperature for 24 h. The reaction mixture was concentrated and distilled to give (S)-diisopropyl malate as colorless liquid. The residual material in the distillation flask was dissolved in EtOH and processed as above. Distillation afforded additional diester, raising the total yield.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. distillationdistilled

출처 및 근거

ORD 기록
ord-b40b84d951c54a0092c8ce12e5f00cd7
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376683B1

반응 노트

불러오는 중…