Hydrochloric Acid → Methyl2-(2,3,4-trifluoroanilino)propionate

HRID 8434

반응식

HRID 8434 반응식
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:11]([O:16][CH3:17])(=[O:15])[C:12]([CH3:14])=O.Cl>CO.[Pd]>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][CH:12]([CH3:14])[C:11]([O:16][CH3:17])=[O:15]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 11748Methyl pyruvateHCID 774682,3,4-Trifluoroaniline

생성물 1

HCID 22015876Methyl2-(2,3,4-trifluoroanilino)propionate수율 81.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

2,3,4-Trifluoroaniline (1.01 g) and methyl pyruvate (0.87 g) were dissolved in methanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa (converted from 30 kgf/cm2) for 2 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.31 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

후처리

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4116153d24484c368b5531235418d367
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087778B2

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