Hydrochloric Acid → Ethyl 2-(2,3,4-trifluoroanilino)propionate

HRID 8437

반응식

HRID 8437 반응식
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:11]([O:16][CH2:17][CH3:18])(=[O:15])[C:12]([CH3:14])=O.Cl>C(O)C.[Pd]>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][CH:12]([CH3:14])[C:11]([O:16][CH2:17][CH3:18])=[O:15]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 12041Ethyl pyruvateHCID 774682,3,4-Trifluoroaniline

생성물 1

HCID 22015871Ethyl 2-(2,3,4-trifluoroanilino)propionate수율 94.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

2,3,4-Trifluoroaniline (0.83 g) and ethyl pyruvate (1.15 g) were dissolved in ethanol (8 ml). After adding 5% Pd—C (0.11 g) and conc. hydrochloric acid (0.03 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (1.32 g) was obtained as slightly yellow oily substance. Various spectral data of this product was identical with those obtained in Example 7.

후처리

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-780ebbded9684dac917e308488340b2f
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087778B2

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