Ethyl isocyanate → HCID 22611366, 화합물

HRID 843784노트

반응식

HRID 843784 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH2:18]([N:20]=[C:21]=[O:22])[CH3:19]>C(Cl)(Cl)Cl>[CH2:18]([NH:20][C:21]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:22])[CH3:19]

참가 물질

4

반응물 2

HCID 8022Ethyl isocyanateHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

생성물 1

HCID 22611366HCID 22611366, 화합물수율 82%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 15.0 mg (0.0655 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole in 3.0 mL chloroform were added 9.3 mg (0.131 mMol) ethyl isocyanate. The reaction was mixed for 48 hours and to it were then added 0.23 gm (0.131 mMol) aminomethylated polystyrene and the reaction mixed for an additional 18 hours. The reaction mixture was then filtered and the volatiles evaporated to give 16.1 mg (82%) of the title compound.

후처리

  1. additionThe reaction was mixed for 48 hours and to it
  2. additionwere then added 0.23 gm (0.131 mMol)
  3. additionthe reaction mixed for an additional 18 hours
  4. filtrationThe reaction mixture was then filtered
  5. customthe volatiles evaporated

출처 및 근거

ORD 기록
ord-8bf8633d889a4f6f9f7249472d006d47
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06380201B1

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