Dichloromethane → 1-Phenylimidazolidine-2-thione

HRID 84396

반응식

HRID 84396 반응식
[C:1](N1C=CN=C1)(N1C=CN=C1)=[S:2].[C:13]1([NH:19][CH2:20][CH2:21][NH2:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(Cl)Cl>C1COCC1>[C:13]1([N:19]2[CH2:20][CH2:21][NH:22][C:1]2=[S:2])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 742701,2-Ethanediamine, N1-phenyl-HCID 802641,1'-Thiocarbonyldiimidazole

생성물 1

HCID 122691081-Phenylimidazolidine-2-thione수율 35.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1,1′-Thiocarbonyldiimidazole (4.51 g, 25.3 mmol) was added to a solution of N-phenylethylenediamine (3 mL, 23.02 mmol) in THF (230 mL) and the mixture was stirred for 2 h at room temperature. DCM was added and the solution was washed with 1N HCl, dried over anhydrous sodium sulfate and concentrated under reduced pressure affording title compound 301 (1.45 g, 8.13 mmol, 35.3% yield). m/z: 179.1 (M+H)+

후처리

  1. washthe solution was washed with 1N HCl
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-092dbad1ebed4eb6801116afed0aba82
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846927B2

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