N-bromobutanimide → HCID 22612209, 화합물
반응식
[Cl:1][C:2]1[CH:6]=[C:5]([Cl:7])[S:4][C:3]=1[CH3:8].C1C(=O)N([Br:16])C(=O)C1>C(Cl)(Cl)(Cl)Cl.CCCCCC.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:16][CH2:8][C:3]1[S:4][C:5]([Cl:7])=[CH:6][C:2]=1[Cl:1]참가 물질
6
반응 조건
- 온도
- 0 °C
실험 절차
A solution of 3,5-Dichloro-2-methyl-thiophene (1.3 grams, 7.8 mmole), NBS (1.4 grams, 7.8 mmole) and benzoyl peroxide (0.065 g) in carbon tetrachloride (40 ml) was refluxed for 18 hours. The mixture was cooled to 0° C., diluted with 40 ml hexane and filtered. The filtrate was concentrated to an oil which was purified via flash chromatography on silica using hexane as eluent to give an oil (1.06 g). MW 245.95; MS (m/e) 246 (M++1).
후처리
- filtrationfiltered
- concentrationThe filtrate was concentrated to an oil which
- customwas purified via flash chromatography on silica
출처 및 근거
- ORD 기록
- ord-bbdb5362085947d6a1a13b12be82f353
- 출처 데이터셋
- uspto-grants-2002_04
- 특허 번호
- US06380218B1
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