Sodium Hydroxide → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8443

반응식

HRID 8443 반응식
[F:1][C:2]1[C:15]([F:16])=[C:14]([F:17])[CH:13]=[CH:12][C:3]=1[NH:4][CH:5]([CH3:11])[C:6]([O:8]CC)=[O:7].[OH-].[Na+]>C(O)C>[F:1][C:2]1[C:15]([F:16])=[C:14]([F:17])[CH:13]=[CH:12][C:3]=1[NH:4][CH:5]([CH3:11])[C:6]([OH:8])=[O:7]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22015871Ethyl 2-(2,3,4-trifluoroanilino)propionate

생성물 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acid수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2-(2,3,4-trifluoroanilino)propionate (2.47 g) was dissolved in ethanol (40 ml) and an aqueous solution (3 mol/l; 10 ml) of sodium hydroxide was slowly added thereto at 0° C. After stirring at room temperature for 3 hours, the solvent was evaporated. After adding water, the residue was washed with chloroform. Next, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value reached 1. Then the aqueous layer was extracted with IPE. The organic layer was dried over anhydrous magnesium sulfate and then the solvent was evaporated to give the title compound (2.19 g) as colorless crystals. Various spectral data of this product was identical with those obtained in Example 23.

후처리

  1. customat 0° C
  2. customthe solvent was evaporated
  3. additionAfter adding water
  4. washthe residue was washed with chloroform
  5. additionNext, hydrochloric acid (6 mol/l) was slowly added to the aqueous layer until pH value
  6. extractionThen the aqueous layer was extracted with IPE
  7. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  8. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-11ea0b2a940b4be2882a47ea40b946fa
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087778B2

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