Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → 2',5'-Dimethoxyacetophenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | 1,4-Dimethoxybenzene | HCID 9016 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 2',5'-Dimethoxyacetophenone | HCID 70991 | 94.8% |
반응 단계
19.3 g of AlCl3 are placed in 200 ml of CCl4 at +5° C. under nitrogen and 11.36 g of acetyl chloride are added, followed by portionwise addition of 20 g of 1,4-dimethoxybenzene. After stirring for 3 hours at +5° C., the mixture is poured into dilute ice-cold HCl solution. The organic phase is separated out and dried over MgSO4 and evaporated, and the residue is then chromatographed on silica, eluting with a DCM/heptane mixture (50/50; v/v) to give 24.71 g of the expected product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06380230B1 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-b4824991047d41b385638006a76309f6 |
| 출처 메모 | uspto-grants-2002_04 |