Methane → 7-amino-[5H]-indeno[1,2-c]pyridazin-3[2H]-one hydrochloride

HRID 845062

반응식

HRID 845062 반응식
C([NH:4][C:5]1[CH:6]=[C:7]2[C:16](=[CH:17][CH:18]=1)[C:10]1=[N:11][NH:12][C:13](=[O:15])[CH:14]=[C:9]1[CH2:8]2)(=O)C.O.C.[ClH:21]>>[ClH:21].[NH2:4][C:5]1[CH:6]=[C:7]2[C:16](=[CH:17][CH:18]=1)[C:10]1=[N:11][NH:12][C:13](=[O:15])[CH:14]=[C:9]1[CH2:8]2

참가 물질

5

반응물 4

HCID 297MethaneHCID 313Hydrochloric AcidHCID 962WaterHCID 201334667-Acetamido-[5H]-indeno[1,2-c]pyridazin-3[2H]-one

생성물 1

HCID 197942087-amino-[5H]-indeno[1,2-c]pyridazin-3[2H]-one hydrochloride

실험 절차

7-Acetamido-[5H]-indeno[1,2-c]pyridazin-3[2H]-one (2.0 g) in 6N hydrochloric acid (20 ml ) was stirred at reflux for 3 hours. Further water (150 ml ) was then added to give a clear, hot solution which was then treated with charcoal and filtered through diatomaceous earth. Concentration of the filtrate gave a buff precipitate of 7-amino-[5H]-indeno[1,2-c]pyridazin-3[2H]-one hydrochloride (1.3 g) which was collected and recrystallised from water (1.1 g, m.p. >300°); ν(Nujol mull) 3200-2000, and 1696 cm-1 ; δ(DMSO-d6) 3.92 (2H,3,5-H2), 6.90 (1H,m,6-H), 7.21 (1H,m,8-H), 7.30 (1H,s,4-H), 7.71 (1H,d,9-H).

후처리

  1. temperatureat reflux for 3 hours
  2. customto give a clear, hot solution which
  3. filtrationfiltered through diatomaceous earth

출처 및 근거

ORD 기록
ord-28108c4a7f174a16a7240944f66ae28e
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04755511

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