1-Phenylcyclohexanecarbonitrile → (1-Phenylcyclohexyl)methanamine

HRID 845124노트

반응식

HRID 845124 반응식
[C:1]1([C:7]2([C:13]#[N:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Ni]>[C:1]1([C:7]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 751481-Phenylcyclohexanecarbonitrile

생성물 1

HCID 205110(1-Phenylcyclohexyl)methanamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

1-Phenylcyclohexane carbonitrile is reduced with H2 in methanol containing 16% ammonia with a Raney nickel catalyst. The catalyst is filtered off and (1-phenylcyclohexyl)methylamine is precipitated as its hydrochloride salt m.p. 230°-33° C., by treatment with methanolic HCl and isopropyl ether.

후처리

  1. filtrationThe catalyst is filtered off
  2. custom(1-phenylcyclohexyl)methylamine is precipitated as its hydrochloride salt m.p. 230°-33° C., by treatment with methanolic HCl and isopropyl ether

출처 및 근거

ORD 기록
ord-22684cdcfb2a427dbdacba43284a77b9
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04755594

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