Benzaldehyde → 1-Cyclohexyl-4-dimethylamino-2-phenyl-2-buten-1-ol

HRID 845145

반응식

C(C1C=C(C(C)C)C=C(C(C)C)C=1S(NN=[C:21]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:22][CH2:23][N:24]([CH2:27]C)[CH2:25]C)(=O)=O)(C)C.[CH:35](=[O:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH:36]1([CH:35]([OH:42])[C:21]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[CH:22][CH2:23][N:24]([CH3:25])[CH3:27])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1

참가 물질

반응물 2

HCID 240Benzaldehyde

HCID 86741730beta-Diethylaminopropiophenone 2,4,6-triisopropylbenzenesulphonylhydrazone

생성물 1

HCID 538458471-Cyclohexyl-4-dimethylamino-2-phenyl-2-buten-1-ol

실험 절차

By using a method similar to that described in Example 22, but starting from β-diethylaminopropiophenone 2,4,6-triisopropylbenzenesulphonylhydrazone (30 g) and benzaldehyde (6.9 cc), 4-diethylamino-1,2-diphenyl-2-buten-1-ol (Z) hydrochloride (3.2 g) is obtained, after recrystallisation from acetone, in the form of white crystals melting at 140° C.

출처 및 근거

ORD 기록: ord-7e88a7e6b815446cb4810f2debc5f5bc
출처 데이터셋: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04755599

연결된 노트

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