Phosphorus oxychloride → 2-Chloro-3-phenylpyridine

HRID 845201노트

반응식

HRID 845201 반응식
[C:1]1([C:7]2[C:8](=O)[NH:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Cl)(Cl)([Cl:16])=O>>[Cl:16][C:8]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][CH:11]=[CH:10][N:9]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 27628082-Hydroxy-3-phenylpyridine

생성물 1

HCID 27628072-Chloro-3-phenylpyridine수율 17%

실험 절차

Using the procedure given above in Example 1, 3-methyl-2(1H)-pyridone (VIII) was refluxed in phosphorus oxychloride followed by work-up to give a 17% yield of 2-chloro-3-methylpyridine (VI).

출처 및 근거

ORD 기록
ord-d1680a9b9c964968a80146063ad902ef
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04757073

반응 노트

불러오는 중…