Hydrochloric Acid → SC 44942-A

HRID 845384노트

반응식

HRID 845384 반응식
[CH3:1][C:2]1([CH3:27])[CH2:26][N:6]2[C:7]3[C:12]([N+:13]([O-:21])=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:5]2=[N:4][CH2:3]1)=[CH:11][C:10]([C:22]([F:25])([F:24])[F:23])=[CH:9][CH:8]=3.[ClH:28]>C(O)C>[ClH:28].[CH3:1][C:2]1([CH3:27])[CH2:26][N:6]2[C:7]3[C:12]([N+:13]([O-:21])=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[C:5]2=[N:4][CH2:3]1)=[CH:11][C:10]([C:22]([F:24])([F:25])[F:23])=[CH:9][CH:8]=3

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 3082690HCID 3082690, 화합물

생성물 1

HCID 3082689SC 44942-A

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2,3-Dihydro-2,2-dimethyl-5-phenyl-8-trifluoromethyl-1H-pyrimido[1,2-a]quinoxaline 6-oxide (70 g) was suspended in ethanol (500 ml) and cooled in an ice-bath. Gaseous hydrogen chloride was passed through the suspension until all solid had dissolved. The solvent was then removed in vacuo and the resulting solid recrystallized from hot ethyl acetate to yield 57.87 g of 2,3-dihydro-2,2-dimethyl-5-phenyl-8-trifluoromethyl-1H-pyrimido[ 1,2-a]quinoxaline 6-oxide hydrochloride as a bright yellow crystalline solid, m.p. 234° C., (Found: C, 58.43, H, 4.68, N, 10.15%; C20H19ClF3N3O requires C, 58.61, H, 4.67, N, 10.25%) and represented by the structural formula: ##STR15##

후처리

  1. temperaturecooled in an ice-bath
  2. dissolutionhad dissolved
  3. customThe solvent was then removed in vacuo
  4. customthe resulting solid recrystallized from hot ethyl acetate

출처 및 근거

ORD 기록
ord-7a7e72a543f34529aa19e7e326bed1e5
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04758565

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