2-Bromopropane → isopropyl 2-chloro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoate

HRID 845966노트

반응식

HRID 845966 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:18](=[O:19])[C:17]3[CH2:20][CH2:21][CH2:22][C:16]=3[N:15]([CH3:23])[C:14]2=[O:24])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[Na].Cl[C:27]1C=CC(N2C(=O)C3CCCCC=3N(C)C2=O)=CC=1C(O)=O.C(Br)(C)C>>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]2[C:18](=[O:19])[C:17]3[CH2:20][CH2:21][CH2:22][C:16]=3[N:15]([CH3:23])[C:14]2=[O:24])=[CH:9][C:3]=1[C:4]([O:6][CH:7]([CH3:27])[CH3:8])=[O:5]

참가 물질

5

반응물 4

HCID 63582-BromopropaneHCID 5360545SodiumHCID 20130616ethyl 2-chloro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d] pyrimidin-3-yl)-benzoateHCID 20130662HCID 20130662, 화합물

생성물 1

HCID 20130708isopropyl 2-chloro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoate

실험 절차

using ethyl 2-chloro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoate via the sodium salt of the corresponding carboxylic acid and isopropyl bromide there is obtained isopropyl 2-chloro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoate, m.p. 148°-150° C.

출처 및 근거

ORD 기록
ord-a2b9a46281ef4a1bb5cf86e049522a9a
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04760163

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