Malonic Acid → 3-Amino-3-(4-fluorophenyl)propanoic acid

HRID 846199노트

반응식

HRID 846199 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[C:10]([OH:16])(=[O:15])[CH2:11]C(O)=O.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][CH:6]([C:5]1[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=1)[CH2:11][C:10]([OH:16])=[O:15]

참가 물질

5

반응물 3

HCID 867Malonic AcidHCID 680234-FluorobenzaldehydeHCID 517165Ammonium Acetate

생성물 1

HCID 5798853-Amino-3-(4-fluorophenyl)propanoic acid수율 23.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 24.8 g (0.2 mol) of 4-fluorobenzaldehyde, 20.8 g (0.2 mol) of malonic acid, 30.8 g (0.4 mol) of ammonium acetate and 550 ml of ethanol was refluxed for approximately seven hours. The mixture was cooled and the precipitated solid was collected by vacuum filtration. The solid was recrystallized from 500 ml of water to provide 8.66 g of 3-amino-3-(4-fluorophenyl)propionic acid. mp=225° C. dec.

후처리

  1. temperatureThe mixture was cooled
  2. filtrationthe precipitated solid was collected by vacuum filtration
  3. customThe solid was recrystallized from 500 ml of water

출처 및 근거

ORD 기록
ord-a69e73985bce4a68ba141535975245a6
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05135947

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