Hydrochloric Acid → isopropyl (2RS,3S)-3-amino-2-hydroxy-5-methylhexanoate hydrochloride
반응식
[NH2:1][CH:2]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH:3]([OH:7])[C:4]([OH:6])=[O:5].[ClH:12].[C:13]1(C)[CH:18]=CC=C[CH:14]=1>C(O)(C)C>[ClH:12].[NH2:1][C@@H:2]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH:3]([OH:7])[C:4]([O:6][CH:13]([CH3:18])[CH3:14])=[O:5]참가 물질
5
실험 절차
3-Amino-2-hydroxy-5-methylhexanoic acid (Example A), 26.5 g (0.164 mol), is dissolved in isopropyl alcohol, treated with hydrochloric acid (anhydrous) for five minutes, treated with toluene (250 ml) and 3A molecular seives and warmed to reflux for 15 minutes. The solution is cooled to room temperature, filtered, and the solvents evaporated in vacuo to give the title compound as an extremely hygroscopic foam, 40 g. The foam is used without further purification.
후처리
- temperaturewarmed
- temperatureto reflux for 15 minutes
- filtrationfiltered
- customthe solvents evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-387fd8d0b14c4ccfb6451d15c30468f0
- 출처 데이터셋
- uspto-grants-1992_08
- 특허 번호
- US05135914
반응 노트
불러오는 중…