Methyl iodide → N-(2,4-Dichloro-5-methoxyphenyl)acetamide

HRID 846501노트

반응식

HRID 846501 반응식
[CH3:1][C:2]([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([Cl:12])=[C:7]([OH:13])[CH:6]=1)=[O:3].[C:14](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[CH3:1][C:2]([NH:4][C:5]1[C:10]([Cl:11])=[CH:9][C:8]([Cl:12])=[C:7]([O:13][CH3:14])[CH:6]=1)=[O:3]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27359882,4-Dichloro-5-hydroxyacetanilide

생성물 1

HCID 14593783N-(2,4-Dichloro-5-methoxyphenyl)acetamide수율 99.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A stirred mixture of 35.0 g (0.16 mole) of 2,4-dichloro-5-hydroxyacetanilide, 33.1 g (0.24 mole) of potassium carbonate, and 34.1 g (0.24 mole) of methyl iodide in 300 mL of acetone was heated at reflux for approximately 18 hours. The mixture was cooled and filtered. The filtrate was evaporated under reduced pressure to leave 37.4 g of 2,4-dichloro-5-methoxyacetanilide as a solid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for approximately 18 hours
  3. temperatureThe mixture was cooled
  4. filtrationfiltered
  5. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f2c8ea1609384ea7857ec011af102844
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05136868

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