Diphosgene → Benzene, 1-chloro-5-fluoro-2-isocyanato-4-methoxy-

HRID 846518

반응식

HRID 846518 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([F:9])[C:6]([O:10][CH3:11])=[CH:5][C:3]=1[NH2:4].Cl[C:13](OC(Cl)(Cl)Cl)=[O:14]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[C:7]([F:9])[C:6]([O:10][CH3:11])=[CH:5][C:3]=1[N:4]=[C:13]=[O:14]

참가 물질

4

반응물 2

HCID 10426DiphosgeneHCID 219564782-Chloro-4-fluoro-5-methoxybenzenamine

생성물 1

HCID 19882833Benzene, 1-chloro-5-fluoro-2-isocyanato-4-methoxy-수율 175.1%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

In the manner of Example 2, Step D, the reaction of 3.0 g (0.017 mole) of 2-chloro-4-fluoro-5-methoxyaniline with 1.68 g (0.0085 mole) of trichloromethyl chloroformate in 20 mL of toluene produced 3.0 g of 2-chloro-4-fluoro-5-methoxyphenyl isocyanate.

출처 및 근거

ORD 기록
ord-93dd89794f3a4d8daaaf0e22382d4d99
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05136868

연결된 노트

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