Benzoyl chloride → HCID 14838556, 화합물

HRID 846845노트

반응식

HRID 846845 반응식
[CH3:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:20](Cl)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CC(C)=O>[CH3:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:12][CH2:13]2)[CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 11430Potassium CarbonateHCID 148385552-Methyl-4-(piperazin-1-yl)pyrimidine

생성물 1

HCID 14838556HCID 14838556, 화합물수율 31.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1 g of 2-methyl-4-piperazino-pyrimidine was dissolved in 50 ml of acetone, and 2 g of potassium carbonate and 0.8 g of benzoyl chloride were added. The suspension was refluxed for 6 h until starting compound was no longer detectable. After filtration, the filtrate was concentrated in vacuo, and the residue was recrystallized from dichloromethane/petroleum ether. 0.5 g of 2-methyl-4-(4-benzoyl-piperazino)-pyrimidine was obtained. (Melting point: 147° C.)

후처리

  1. temperatureThe suspension was refluxed for 6 h
  2. filtrationAfter filtration
  3. concentrationthe filtrate was concentrated in vacuo
  4. customthe residue was recrystallized from dichloromethane/petroleum ether

출처 및 근거

ORD 기록
ord-af8933921ef245bfa503c24ec577effe
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05138058

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