Ethyl bromoacetate → Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate

HRID 847117

반응식

HRID 847117 반응식
[OH:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.Br[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([O:1][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:3]=1

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 95084,6-Dimethylpyrimidin-2-olHCID 11430Potassium Carbonate

생성물 1

HCID 3410252Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate수율 26.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2-Hydroxy-4,6-dimethyl pyrimidine (10g, 0.08 mol) was dissolved in 150ml of dimethylformamide. Ethyl bromoacetate (13.5g, 0.08 mol) was added and also, subsequently, 11.lg of potassium carbonate. The reaction mixture was refluxed overnight. A precipitate had formed which was filtered off and the solvent was then evaporated off from the filtrate to form a crude oily product. Following purification by flash chromatography, 4.5g of the title product were obtained in the form of a red oil.

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. customA precipitate had formed which
  3. filtrationwas filtered off
  4. customthe solvent was then evaporated off from the filtrate
  5. customto form a crude oily product
  6. custompurification by flash chromatography

출처 및 근거

ORD 기록
ord-83d2bb0b404543c793d87e333bd2852c
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05139563

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