Sodium Hydroxide → 2-((4,6-Dimethylpyrimidin-2-yl)oxy)acetic acid

HRID 847118

반응식

HRID 847118 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([O:9][CH2:10][C:11]([O:13]CC)=[O:12])[N:3]=1.[OH-].[Na+]>C(O)C>[CH3:8][C:6]1[CH:7]=[C:2]([CH3:1])[N:3]=[C:4]([O:9][CH2:10][C:11]([OH:13])=[O:12])[N:5]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 3410252Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate

생성물 1

HCID 198818052-((4,6-Dimethylpyrimidin-2-yl)oxy)acetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2g (9.5mmol) of the ethyl ester prepared in Example 7 were dissolved in 20ml of ethanol. 25ml of an aqueous solution (10% by vol) of sodium hydroxide were then added to the solution. The reaction mixture was refluxed for 4 hours. After the reaction was complete, as confirmed by thin layer chromatography, the ethanol was evaporated off, the aqueous residue cooled, acidified to a pH of 2 and the product extracted into chloroform. Following drying first over anhydrous sodium sulphate and then by evaporation, 0.6g (yield 35% by weight) of a reddish oil were obtained which oil crystallised on standing.

후처리

  1. temperatureThe reaction mixture was refluxed for 4 hours
  2. customthe ethanol was evaporated off
  3. temperaturethe aqueous residue cooled
  4. extractionthe product extracted into chloroform
  5. dry with materialFollowing drying first over anhydrous sodium sulphate
  6. customby evaporation

출처 및 근거

ORD 기록
ord-c66387b1542d44ae88d0c2fcdcc585d9
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05139563

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