1-(Trimethylsilyl)pyrrolidin-2-one → 1-(4'-Bromophenoxycarbonyl)-2-pyrrolidinone

HRID 847222

반응식

HRID 847222 반응식
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=[O:3].C[Si](C)(C)[N:14]1[CH2:18][CH2:17][CH2:16][C:15]1=[O:19]>C1C=CC=CC=1>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][C:2]([N:14]2[CH2:18][CH2:17][CH2:16][C:15]2=[O:19])=[O:3])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 844611-(Trimethylsilyl)pyrrolidin-2-oneHCID 52377364-Bromophenyl chloroformate

생성물 1

HCID 197515271-(4'-Bromophenoxycarbonyl)-2-pyrrolidinone수율 53%

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

To a solution of 4-bromophenyl chloroformate (4.19 g, 20.0 mmol) in anhydrous benzene (20 ml) was added a solution of 1-trimethylsilyl-2-pyrrolidinone (3.46 g, 22.0 mmol) in anhydrous benzene (10 ml). The mixture was stirred at room temperature for 30 min. The reaction mixture was evaporated under reduced pressure to dryness to give a solid material. Recrystallization from 2-propanol afforded 3.00 g of colorless prisms. Yield 53%

후처리

  1. customThe reaction mixture was evaporated under reduced pressure to dryness
  2. customto give a solid material
  3. customRecrystallization from 2-propanol

출처 및 근거

ORD 기록
ord-84b29e23496146fe8a04e42fd72c8965
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05140041

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