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1-(2-Pyrimidinyl)piperazine → 2-(2,4-Diphenyl-imidazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

HRID 84773
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인쇄 미리보기

반응식

HRID 84773 반응식
[N:1]1([C:7]2[N:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:13]1([C:19]2[N:20]([CH2:30][C:31](O)=[O:32])[CH:21]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:23]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[C:13]1([C:19]2[N:20]([CH2:30][C:31]([N:4]3[CH2:5][CH2:6][N:1]([C:7]4[N:8]=[CH:9][CH:10]=[CH:11][N:12]=4)[CH2:2][CH2:3]3)=[O:32])[CH:21]=[C:22]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:23]=2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 887471-(2-Pyrimidinyl)piperazineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 86686623(2,4-Diphenyl-imidazol-1-yl)-acetic acid

생성물 1

HCID 715865822-(2,4-Diphenyl-imidazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone수율 48.4%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

40 mg 2-piperazin-1-yl-pyrimidine was added to 70 mg (2,4-diphenyl-imidazol-1-yl)-acetic acid, 80 mg TBTU, 50 μL TEA in 1 mL DMF. The reaction was stirred overnight at RT. The mixture was purified by HPLC to give 50 mg desired product.

후처리

  1. customThe mixture was purified by HPLC

출처 및 근거

ORD 기록
ord-000f2c008bf444348603f18d2754f9fe
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846948B2

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