Hydrochloric Acid → 4-[3-(4-Fluorophenyl)propyl]piperidine

HRID 848159노트

반응식

HRID 848159 반응식
C([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][C:17]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)=O)[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.Cl>>[F:25][C:22]1[CH:21]=[CH:20][C:19]([CH2:17][CH2:16][CH2:15][CH:12]2[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]2)=[CH:24][CH:23]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 545157143-(1-Benzoyl 4-piperidyl) 1-(4-fluorophenyl) 1-propanone

생성물 1

HCID 30590224-[3-(4-Fluorophenyl)propyl]piperidine수율 55.1%

실험 절차

The procedure is as in Example 6 starting from 24.2 g of 3-(1-benzoyl 4-piperidyl) 1-(4-fluorophenyl) 1-propanone. 8.7 g of 4-[3-(4-fluorophenyl)1-propyl]piperidine are obtained in the form of the hydrochloride melting at 142° C.

출처 및 근거

ORD 기록
ord-0f975272f4e940d5a0cf21a999f3db18
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04294841

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